The additional bolt holes should not affect the integrity of your trailer frame. They expect you to drill holes into the frame channel to bolt a plate onto the frame.
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Drilling holes in trailer frame. Both of these items expect to go onto a boxed channel beam. Wow i must get out more ive never seen any failures of any travel trailers frames none. The easiest install would be to drill 2 holes 516 about 6 inches apart in the top of one side of the frame. I can bolt around the frame but it wouldnt be as secure. When building airplanes we drilled holes into the aluminum wing ribs to make them lighter then we used a roller to form a lip none of them failed either. The holes are far enough apart that you would be fine.
I attached a picture that shows how to find the correct spot. Drilling steel or metal is a quick way to dull your drill bits if you do it the wrong way. Step up to 14 or 38 you will want at least 38 or 12 inch bolts depending on load capacity. And the wd take up expects to clamp around the channel. If i re drill these holes in the appropriate position how much am i weakening the trailer frame. Drill the first hole using 18 drill bit.
Is it ok to drill holes into my v channel frame or should i reinforce box these areas especially the area where the takeups go. You can drill with one bit size but it will go faster drilling stepping up in sizes. Be sure you locate the bracket in the correct position on your trailer frame. Basically all holes need to move 15 2 inches back. If i needed a 78 hole in a trailer frame to make my life easier to retract the slide id drill the hole. If you are drilling through steel it is easiest to drill in steps.
I suspect that there is going to be little change in the integrity of the frame but i am not an engineer so thats why i am asking here.